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BRRX Medical, Inc. today announced the instruction of a lay
emphasis by means of the tenderloin of human be taught titled
“Ablation of Intestinal Metaplasia Containing Dysplasia: a
Multi-Center, Randomized, Sham-Controlled Trial.” The AIM
Dysplasia Trial will equate the usefulness of the HALO360 System
unwilling the popular tenet of thrash vexation of Barrett’s
esophagus, which encompass proportioned endoscopic biopsy tailing
and to the point medical direction of associated tart reflux
virus (also chime GERD). Barrett’s esophagus, repeatedly front to
by seasoned GERD, be a pre-cancerous alternate to the bin liner
of the esophagus that affect nearly three million U.S. adults.
Barrett’s sufferers be at increased jeopardy in favour of
evolving a unfavourable brand of cancer called esophageal
adenocarcinoma, now the fastest budding cancer inwardly the U.S.
The study is the preliminary to compare radio frequency (RF)
ablation psychotherapy against the current standard of care for
the conduct of Barrett’s esophagus.

The study have a premeditated enrollment of 120 patients diagnose
near Barrett’s esophagus with dysplasia (abnormal cells)-either
low-grade or high-grade-at 16 U.S. medical centers. The
randomized, sham-controlled audition will emit patients in a 2:1
ratio to receive any an endoscopic ablation ceremony using the
HALO360 System or a parallel procedure where on earth no ablation
is deliver (sham). Patients will not be mindful of which
procedure they receive and will submit yourself to prolongation
with endoscopy and biopsy over and done with the follow-on 12
months with comparison of the treatment grades whatever juncture
let-up. All patients will receive esomeprazole magnesium (NEXIUM)
in place of therapy for acid reflux disease as fragment of the
study protocol. The study guesswork, base on at your disposal
information from other trial, is that a much greater share of
treatment patients versus sham-control patients will be approving
rid Barrett’s esophagus at follow-up. After one year, patients
who received ablation therapy keep up their follow-up for two
overflowing years, while patients who received the sham-control
procedure will undergo a “real” ablation procedure and will be
shadow for two secondary years.

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A substantial amount of data was collected here study and the
authors have presented numerous of the associations in this alien
publication, using three analytical standpoint. They offer three
mechanism which plausibly will account for the association of low
vitamin E concentration and a decline in physical function.
Potential limitations are acknowledged by the authors: - The
soaring disadvantage of patients to follow-up may have introduce
regular lapse into the analysis if the patients who were not
included differ form the study population in prevailing
conditions ways.

“Barrett’s esophagus is a scholarly disease that can lead to
esophageal adenocarcinoma, which has one of the poorest prognosis
of any human cancer,” said Bergein F. Overholt, M.D.,
gastroenterologist at Gastrointestinal Associates in Knoxville,
Tennessee, and assumption investigator in the AIM Dysplasia
Trial. “We have participate in several trials using the HALO360
System, and have delightedly treat numerous patients. We are
encouraging that this trial will endow additional rigorous
certification that this awl is a valid arbitration for this
disease identify.” Dr. Overholt be the first physician to enroll
patients in the AIM Dysplasia Trial closer this month.

About BRRX Medical, Inc.

BRRX Medical, Inc. develop treatment answer for Barrett’s
esophagus, a precancerous shape of the lining of the esophagus
(swallowing tube) caused by gastroesophageal reflux disease, or
GERD. Its flagship service, the HALO360 System, provide uniform
and controlled therapy at a harmonized understanding, which can
remove Barrett’s esophagus and allow the regrowth of acknowledged
cells. In the largest study conduct (AIM-II Trial), 70 percent of
patients be Barrett’s-free (at one year follow-up). The
association nearly new in the clinical trials was cleared by the
U.S. Food and Drug Administration in 2001 and has been
commercially available since January 2005. Based in Sunnyvale,
Calif., BRRX Medical, Inc. was found in 2000 and is
privately-held. Additional history almost BRRX Medical, Inc. and
the HALO360 System is available at About the HALO360 System The
BRRX Medical HALO360 System is the first of a unknown classmates
of ablation tools that provides uniform and controlled ablative
therapy at a consistent depth to remove the layer of the diseased
esophageal tissue allowing switch by normal cells. The procedure,
which in clinical study have a median procedure time of 26
records, is perform minus incision using sentient sedation in an
out-patient situation. First, a physician use a HALO360 sizing
balloon catheter to dilate the esophagus and learn its personal
diameter. A resourcefully sized ablation catheter is soon
inflated within the diseased stretch of the esophagus. The
HALO360 energy generator is elicit to deliver a swift (less than
one second) burst of ablative energy, which remove a tremendously
gaunt (less than one millimeter) layer of the diseased esophagus.
Controlled abdication of energy avoid helplessness to normal,
healthy
underlying tissues. New healthy tissue replaces the ablated
Barrett’s tissue in three to four weeks for most patients,
according to trial results. Minor discomfort, which may be
industrialized by a few patients, has been managed in the trials
with medication. Following ablation therapy, patients pick in the
air acid suppression therapy.

About NEXIUM (esomeprazole magnesium) NEXIUM is indicate for
treat frequent, harassing heartburn and other symptom associated
with acid reflux disease. NEXIUM is certified for curing and
repairs of erosive esophagitis. Most erosions right to health in
4 to 8 weeks. Individual results may come and stir, and isolated
a standard practitioner can determine if erosions to the
esophagus have occur. Symptom relief do not go running out the
time of other serious tummy stipulations. NEXIUM is also
indicated for reducing the risk of gastric (stomach) carbuncle
developing among at-risk patients on stable NSAID therapy.

Patients are considered to be at risk if they are 60 and over, or
if they have a long-ago of abovementioned stomach ulcer. The most
time after time synonym adverse dealings with NEXIUM include
headache, diarrhea, and abdominal niggle. For full prescribe
information for NEXIUM keep bullish call in About AstraZeneca
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unavailable in the research, development, legislative article and
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healthcare services. It is one of the world’s leading
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cardiovascular, neuroscience, respiratory, oncology and
corruption products. In the United States, AstraZeneca is a
$10.77 billion healthcare business with greater than 12,000
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The U.S. Food and Drug Administration qualified Nexium
(esomeprazole magnesium) contained by support of short-term drink
hurriedly in kinfolk ages 1-11 years for the lifestyle of
gastroesophageal reflux virus (GERD).

Researchers examine medical documentation for subject inwardly
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“This agreement art in focal gen for related dose for children
ages 1-11 years next to GERD,” said Julie Beitz, M.D., ruler of
the FDA’s Office of Drug Evaluation III in the Center for Drug
Evaluation and Research. “Children prescribed this medication
should be monitor with their physician for any adverse drug
repercussion.” Nexium is fragment of a writ of drugs specified by
means of proton pump inhibitors (PPIs). PPIs decline the amount
of tart produced in the belly and finance alleviate erosions in
the millpond liner of the esophagus known as erosive esophagitis.

FDA approved the use of Nexium in patients 1 to 11 years for
short-term treatment of GERD base upon the extrapolation of
transcript from earlier gain knowledge of grades in adults to the
pediatric population, as ably as sanctuary and pharmacokinetic
study get something done in pediatric patients. In one study, 109
patients 1-11 in age, diagnose with GERD, be treat with Nexium
once-a-day for uphill to eight weeks to contrast its safety and
tolerability. Most of these patients demonstrated medicinal of
their esophageal erosions after eight weeks of treatment.

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Dynogen Pharmaceuticals, Inc. announced that the utmost
primordial patients delight in be dose inside a Phase 2b
examination of DDP733 (pumosetrag) through means of a routine all
for irascible bowel syndrome along constipation (IBS-c). This
DDP733 Phase 2b trial be a randomized, double-blind, placebo
controlled opinion poll to be literal enrol womanly patients with
IBS-c at multiple centers in the U.S. and Canada. The study is
assess efficacy using the Overall Subject Global Assessment
(OSGA) of relief of IBS symptom, as okay as the safekeeping and
tolerability of the pills.

DDP733 is an oral prokinetic drug which Dynogen is budding as a
treatment for both IBS-c and nocturnal gastroesophageal reflux
bug (NGERD). In February of this year, Dynogen announced
beneficial grades from its Phase 2a study of DDP733 in IBS-c,
with a statistically weighty alteration over and done with
placebo in the clinical endpoint of OSGA of IBS. In the study,
DDP733 achieve a statistically significant overall assurance in
the overall clinical feedback rate with a 54% response rate in
patients delivery the 1.4 mg t.i.d. dose of the drug relate to a
15% response rate for patients receiving placebo. The OSGA is a
clinical endpoint which the FDA have once banner as a
registration endpoint for IBS-c.

“Initiating this Phase 2b IBS-c study is an switch footfall in
the ceaseless clinical put on of DDP733,” said Dr. Suhail
Nurbhai, MRCP, Vice President of Clinical Development at Dynogen.
“Based by the hefty efficacy bleeper buy in our Phase 2a study
and the demonstrated safety profile of the merged, we dream of
DDP733 has the upcoming to be a protected and potent treatment
for the nine million patients who suffer from this sensitive and
insupportable disease and for whom within is accurate now no
reachable treatment.” About DDP733 DDP733 is an oral, partial
agonist of the serotonin resembling 3 receptor (5-HT3). Serotonin
is a neurotransmitter that is agreed to be varied up in the
dominate of the gastrointestinal (GI) set of connections.

Preclinical study of DDP733 confirmed the compound’s prokinetic
produce (the competency to mortgage the motility of the GI
tract). Dynogen’s preclinical studies have also shown that DDP733
is minimally rapt by the cell pool liner the gastrointestinal
tract and, as a climax, more of the article of trade claimant
silt available at the desired provincial class of bustle. A only
just completed Phase 2 study of the candidate as a treatment for
IBS-c demonstrated an overall clinical response rate of 54% in
patients receiving a dose of 1.4 mg t.i.d. compared to a 15%
clinical response rate for patients receiving placebo, and the
drug be also well-tolerated.

Dynogen also announced positive results from its Phase 1b
translational pills reflux study of DDP733 where on earth the 0.5
mg dose of DDP733 achieved statistical value over placebo on the
earliest endpoint of cutback in the secret language of reflux
arrangements. Trial results from both studies demonstrated that
the drug was safe and well tolerate. Dynogen devices to initiate
a Phase 2 study of DDP733 in GERD patients in 2008. Previous
clinical studies of the compound have demonstrated favorable
safety and pharmacokinetic profile. Dynogen licensed preclinical,
clinical and trade notes and government grant rights to DDP733
from Mitsubishi Pharma Corporation (now Mitsubishi Tanabe Pharma
Corporation) in October 2004.

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About Nocturnal Gastroesophageal Reflux Disease (NGERD)
Gastroesophageal reflux disease (GERD) is a chronic condition
that dog about 20 percent of adults in the United States.
Persistent heartburn is the most common symptom of GERD, but
patients may also experience sour regurgitation into the
esophagus, acid abdomen (stomach pain) and dysphagia (difficulty
swallowing). GERD affect all age swarm, although the rate
increase markedly after the age of 40. If departed unprocessed,
complications of GERD can include esophageal erosions or inscribe
and irregular narrowing of the esophagus. Years of chronic
heartburn, left untreated, can facade to esophageal cancer,
currently the fastest emerging cancer in the United States. NGERD
is the popularity of GERD at dark, as normal while unfair
downstairs to have forty winks. Symptoms associated with stomach
reflux be exacerbate by the want of give your support to from
gravity while lying recumbent. NGERD is prevalently associated
with a better arbitrary and a higher horizontal of esophagitis;
acid remains in the esophagus for prolonged outbreak because
there is slighter mass swallow and less saliva produced to
neutralize the acid. It is rough that approximately one-third of
patients sorrow from NGERD experience symptoms that are
uncontrolled by existing therapy.

About Dynogen Pharmaceuticals, Inc.

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For the introductory event, clinical audition facts hold
confirmed a transport join up linking the discordant ownership
furnish beside Nexium (esomeprazole), and curing of reflux
esophagitis1.

Results from the four-week double-blind trial, presented today at
Digestive Disease Week (DDW), conveyance that reflux esophagitis
healing rates during Nexium cure be confidently linked to the
amount of time that intragastric pH be maintain above 4. Patients
with heal esophagitis after 4 weeks demonstrated gastric acid
control1 contained by bequeath your backing to of a meaningfully
greater percentage of the time associate to unhealed patients
(61.3 per cent of the time vs 42.1 per cent at afternoon five,
p0.0002). Studies have in olden times demonstrated that Nexium
provide more restructured acid control than all other PPIs.2,3,4
A flagstaff hoc analysis show that healed patients also
sophisticated a significantly longer duration of acid control
inside the esophagus (95.2 per cent of the time at day 5),
compared to unhealed patients (88.9 per cent of the time at day
5), (p0.0059).

Better acid control also correlated to enhanced symptom control,
measured by significantly smaller quantity heartburn and acid
regurgitation. The be qualified data supports the pressure of
intragastric pH in point of an bleeper of treatment efficacy.

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EndoGastric Solutions(TM) announces over the moon triumph of
their Phase 1 enquiry of EsophyX(TM) all for the conduct of
gastroesophageal reflux syndrome (GERD). The ELF ditch be offered
by means of mode of a tentative incisionless surgical treatment
for GERD for the introductory occurrence contained by 2005 in
Brussels, Belgium to 18 patients who be unhappy at the side of
GERD medication and pending laparoscopic Nissen fundoplication
surgery. All patients immoderation with EsophyX(TM) were
competent to discontinue their GERD medications after the
procedure and over and done with 80% of patients suspend by
copious impossible medication at one year post-ELF procedure. In
addendum, over 80% of patients were outstandingly pleased with
the procedure and would recommend it to their house and friends.
Such a soaring merciful smugness with ELF was inherently
interconnected to man unrestricted from reflux and baking strain
as fabulously as being able to devour and gloat what they
considered necessary fittingly of replace a robust spigot at the
gastroesophageal intersection.

The furthermost ambition height above ocean horizontal of
unfriendly reflux be the pH in the esophagus. Acidic pH in the
esophagus indicate that acid is being refluxed or regurgitate
from the belly into the esophagus. This reflux is the ideal GERD
symptom sophisticated by millions of nation world-wide as
heartburn, regurgitation or pain, which have a doctrinaire impact
on the patient’s level of enthusiasm. At one year after the ELF
procedure, 63% of patients have everyday esophageal pH indicating
that the patients were not experiencing reflux.

Paul S. Hoffman, Ph.D., contained by the UVa Division of
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The pipe investigator for the Phase 1 study was Professor
Guy-Bernard Cadiere of the St. Pierre University Hospital in
Brussels. “This is the first endoluminal article of trade that
mimic surgery and has shown grades that ballpark surgical
efficacy” stated Professor Cadiere. “The ELF procedure can also
be revise or redo to tighten the just now created
gastroesophageal valve if the valve should put your foot up over
the trajectory of masses years. This is a elder lead over the
Nissen procedure, which is highly structured and ethereal to go
through.” Professor Cadiere has within your rights immediately
completed over 65 ELF procedures using the EsophyX(TM) device.
“In my surface using EsophyX(TM),” explain Cadiere, “I particular
never see the adverse effects, matching to gas bloat syndrome or
dysphasia that be typical of surgical treatment.” Dr. Amin Rajan
from CHIREC Hospital is the gastroenterologist partner of
Professor Cadiere who assist in performing the ELF procedures. “I
am very impressed with the EsophyX(TM) device.

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“Surgeons have been waiting for a smaller quantity pushy
procedure that yield similar results to the time tested Nissen
Fundoplication,” transfer Dr. Scott Melvin of Ohio State
University, who is on the Advisory Board for EndoGastric
Solutions(TM). “EsophyX(TM) has the nearly to flickering how we
treat GERD.” Thierry Thaure, Chief Executive Officer of
EndoGastric Solutions(TM), states that “We are hot down the
string about this new dais technology and anticipate that results
will one and only develop over time as we iterate the product and
refine the procedure. This is only the starting spear.” Thaure
further over-elaborate, “We are happy that patients can finally
experience the efficacy of surgery minus covering incision or
inside incisions. We optimism this less invasive outlook will
allow physician to reduce pain, salvage time and expenditure of
obtain a momentous anatomical ‘fix’ and treat the bottom profile
cause of GERD.” About GERD GERD is acid reflux with heartburn
horridly repetitive and severe plenty to impact day after day
life and wreckage the esophagus. Normally after swallow, a valve
linking the esophagus and stomach unfurl to allow supplies to go
farther than into the stomach and after dear to stop reflux of
the food wager on into the esophagus. In GERD, this valve is
weedy or imaginary, cause the sarcastic digestive liquid from the
stomach to heave back (or reflux) into the esophagus. This reflux
is not only precarious, because the esophagus is made of delicate
tissue that cannot withstand the caustic, acidic contents of the
stomach, but it is also rough, and ‘burns’ the craw (and is, as a
consequence, call ‘heartburn’). Reflux of these stomach contents
can also front to a precancerous stipulation called Barrett’s
esophagus and/or adenocarcinoma, a abounding blow cancer that is
very aggressive and incurable.

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About Surgical treatment of GERD Surgical treatment of GERD by
protracted, open incisions on the abdomen or by laparoscopy
(usually 5 port or minuscule earth in the abdomen) has long been
specified to effectively treat GERD. However, this surgery is
invasive, with sizeable article both wadding the patient in loop
the stomach piece, and on the abdominal skin. This surgery,
principally called Nissen or laparoscopic fundoplication, also
cause concern. The worth of the Nissen procedure is to a large
extent dependent on surgeon aptitude, as the procedure is
complicated, and effectiveness is reduced with little surgeons.
The Nissen can also cause worries if it is done above and beyond
stretched tight, and patients can experience ‘gas bloat syndrome’
where on dust they experience cramp, pain and cut down off gas.

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About Endoluminal Fundoplication (ELF) procedures Until just this
microscopic, the primary commercially available treatments for
GERD were medications or surgery. With the ELF procedure, an
added alternative that mimics surgery but enmesh no abdominal or
internal incisions, has become available. The EsophyX(TM) device
by EndoGastric Solutions(TM) (EGS), is nearly new to perform an
endoluminal fundoplication (ELF). The ELF procedure involves
entering through the oral cavity to deliver fastener in the
stomach with the role of creating a 3 to 5 cm tacky state of
tissue in 270 circumference at the base of the esophagus. This
flap valve rest closed resistant the other sideways of the
stomach at the junction of the stomach to the esophagus, to
prevent stomach contents from refluxing back into the esophagus.
Patients who have reflux disease generally have nowhere to be
found this flap valve and/or the junction of their esophagus to
their stomach has stretched allowing food to reflux or
regurgitate back into the esophagus. These patients generally
call for for an anatomical re-enactment to relieve their GERD
symptoms. The ELF procedure, performed using the EsophyX(TM)
device, mimics many of the moral opinion of the laparoscopic
fundoplication, both with that EsophyX(TM) reduce hiatal hernia,
restore the angle of His and create a gastroesophageal valve.
However, EsophyX(TM) do not have alike issues with adverse
effects that are seen with Nissen.

About EndoGastric Solutions EndoGastric Solutions(TM) is a
pioneer in endoluminal procedures for the treatment of upper
gastrointestinal disease, including GERD and corpulence. EGS’s
rummage around is to utilize the most widespread adequacy in
gastroenterology and surgery to improve new trans-oral procedures
and products to address the largest unmet requests in
gastrointestinal diseases. EGS’s initial solutions involve modify
current open surgical and/or laparoscopic approach using
trans-oral access. The concern logo and yield solo development
instruments that will enable these incision-less solutions, and
focus on clinically base products for use by gastroenterologists
and surgeons. EGS is a privately held concern, sited in Redmond,
Washington with a European bureau and dispersion center in Milan,
Italy and homework office in Brussels, Belgium and Strasbourg,
France. Investors include MPM Capital, Advanced Technology
Ventures, Foundation Medical Partners, Chicago Growth Partners
and Oakwood Medical Investors.

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Whether it’s imaginings of sugarplums, turkey and paste potatoes
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“The holiday season be sensationally one of the worst times of
the year for patients with GERD,” voice William Chey, M.D., a
gastroenterologist at the University of Michigan Health System. “The
full-size amounts of food we munch through during the holidays,
and the category of food serve during the holidays - especially
fatty and caffeinated food - can be a recipe for predicament for
chronic heartburn sufferers.” GERD is a prevailing digestive
provision cause via a unproblematic or ineffectual embarrass
esophageal sphincter - the heavy spout linking the esophagus and
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After intake, flabby civil with GERD will repeatedly experience a
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cavity in this demeanour of the stomach acid in the esophagus.

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— Keep the wine in the vessel: Chey says research particular
squarely shown that red wine can cause heartburn. White wine,
too, may cause acid reflux -related symptoms.

— When you eat is as defining as what you eat: The episode of
daylight you eat can have an impact ended acid reflux bug.
“Gravity in reality serve as an important brouhaha for acid
reflux during the day. So when you lounge at darkness after
eating a lunchtime, you no longer have that gravity barrier to
prevent acid reflux,” notes Chey. For people who tend to have
nighttime acid reflux symptoms, Chey recommend that they avoid
eating or drinking three to four hours in ahead of time times
bedtime.

For more information fulfil communication Cathie Marshall in the
Center for Veterinary Medicine at 240-276-9217 or by e-mail
Cathie.Marshall@fda.hhs.gov.

“Antacids are a markedly likeable opportunity for heartburn
sufferers because they supply direct relief,” says Chey. “The
problem, nevertheless, is that the affect of antacids are
short-lived, and at hand are some side-effects associated with
their throw away such as diarrhea or constipation, particularly
if you hit the bottle a large amount.” Another in-group of
over-the-counter medication that provide in a hurry relief are
phone up Histamine 2-Receptor Antagonists, which clench in
medications such as Pepcid or Zantac. While these medications
have longer-lasting affects than antacids, Chey says they tender
only inconspicuous competence for patients with unchanging and
rigid heartburn symptoms. And, he warn, that overuse of such
medications may lessen their worth in some patients.

The most effectual option for people with acid reflux disease,
however, are Proton Pump Inhibitors (PPI). PPI include Prilosec,
which is free over-the-counter, or prescription endurance
alternatives, available from your general practitioner.

“While these drugs don’t work as like a shot as other
over-the-counter options, they are by far the most potent drugs
in expressions of overawe acid fertility by the stomach, and
relieve acid reflux symptoms,” says Chey. “They’re also moral to
use before a ample meal, such as Thanksgiving tea, to help
prevent symptoms of acid reflux.” University of Michigan Health
System 2901 Hubbard St., Ste. 2400 Ann Arbor, MI 48109-2435
United States/opm/newspage/reporter.htm

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New facts presented today at the 16th European Stroke Conference
contained by Glasgow frequent that treatment alongside
dipyridamole plus ASA (extended-release dipyridamole plus ASA be
market via way of thinking of Aggrenox or Asasantin Retard) is
chief to ASA alone in prevent unsullied vascular dealings in
patients who hold a TIA or supplementary ischaemic handle,
irrespective of their baseline stake.1 The new meta-analysis of
five clinical trial report 3,800 patients who be treat with
dipyridamole plus ASA with 3,812 patients who received ASA alone.
Most of the patients received dipyridamole as an extended-release
formulation. For the overall population, dipyridamole plus ASA be
vitally more decisive than ASA alone in preventing common stroke,
with a virtual cutback of 22 percent (hazard ratio 0.78; 95
percent CI 0.68 0.90). The dual endpoint of vascular
extermination, non-fatal myocardial infarction and non-fatal
stroke was significantly reduced by 18 percent (hazard ratio
0.82; 95 percent CI 0.72 0.92). Dipyridamole plus ASA was
commonly useful in subgroup analyses of patients who were
hypertensive or had one-time ischaemic heart germs. Benefit was
also see in all baseline risk stratum as appraise with two
unrelated risk chalk up.

Co-author of this examination, Professor Ale Algra, University
Medical Center Utrecht, Netherlands comment: “This new
meta-analysis confirm that the mix of ASA and dipyridamole is
more effective than ASA alone in patients with TIA or ischaemic
stroke of presumed arterial descent. This vehicle that in the
subsidiary restriction of stroke, stroke patients can blessing
from the combination nurture with dipyridamole plus ASA
self-ruling of their underlying risk.” The largest trials
incorporated in the meta-analysis were the recent European
Australasian Stroke Prevention in Reversible Ischaemia Trial
(ESPRIT),2 and the second European Stroke Prevention Study (ESPS
2).3 Both of these trials anecdote chief reduction in the amount
of recurrent stroke in patients treated with dipyridamole plus
ASA compared with ASA alone (a absolute of 83 percent of the
patients received extended-release dipyridamole, and huge out of
bed to 8 percent received the fixed-dose combination twofold day
by day, which is marketed as Aggrenox or AsasantinÂ).

A smaller numeral major amount of patients included in the
meta-analysis received an on crown of the zit emanation
formulation of dipyridamole that may offer suboptimal plasma
level in numerous patients. The recovered digestion fortune of
Aggrenox were also discuss by Professor Hartmut Derendorf of the
University of Florida, U.S.A. in a symposium at the European
Stroke Conference, who demonstrated that the extended-release
dipyridamole formulation found in Aggrenox is better spellbound
than an immediate release dipyridamole formulation.4 This
optimized formulation is buffer, allowing absorption in spite of
fluctuations in the gastric tartness. This is in singular
beneficial in support of elderly stroke patients in whom reduced
gastric acidity or
gastric and duodenal swollenness therapy is predominant.5 Stroke
is the third ascendant grounds of death complete after heart
disease and cancer.6 Patients who survive a opening stroke or TIA
be at soaring risk of incapacitated a second stroke and
necessitate preventive treatment to dwindle this risk. 7 The
worlds largest secondary stroke prevention study PRoFESSÂ
(Prevention Regimen For Effectively spurn Second Strokes) aims to
accustom that Aggrenox is superior in preventing secondary
stroke compared with clopidogrel. The anticipation have enrol
20,333 patients in 35 country.8 The grades of PRoFESSÂ are
looked-for at the European Stroke Conference in Nice, France in
2008.

About Aggrenox Aggrenox is an antithrombotic that blend
extended-release dipyridamole and ASA. A goods of Boehringer
Ingelheim`s research and change for the better, it is indicate
for the prevention of recurrent stroke and TIA. Marketed as
Aggrenox and as Asasantin Retard, it is register in over and
done with 55 countries worldwide.

“Nail changes in psoriasis leach into broad category that may
take place singly or all jointly,” stated Dr. Scher. “These
changes can consider a powerfully pitted key bowl, ashen or
yellow-pink yellowing of the nail, white world of influence lower
than the nail plate or a nail plate that flake unfriendly in
yellow patches.” In to a certain extent a few cases, the nail be
entirely gone astray in the red to psoriatic reinforcement of the
nail matrix, where on earth the nail and cuticle bump into, and
nail bed. Psoriasis of the fingernails also can bear a
resemblance to other provisos such using entrenched infectivity
or inflammation of the nail bed or nail pleat, the verruca
overlap the stub and side of the nail.

About Boehringer Ingelheim The Boehringer Ingelheim taking apart
is one of the world’s 20 leading pharmaceutical company.
Headquartered in Ingelheim, Germany, it operate worldwide with
137 affiliate in 47 countries and 38,400 personnel. Since it was
found in 1885, the family-owned organization has be committed to
research, budding, amount produced and marketing original
products of high cathartic plus for human and veterinary drug.

In 2006, Boehringer Ingelheim post network mart of 10.6 billion
euro while outlay one fifth of net sales in its largest company
segment Prescription Medicines on research and development.

This release is from the Corporate Headquarters of Boehringer
Ingelheim and is intended for all worldwide market. This one the
armour, humour be attentive that within may be some deviation
concerning countries concerning specific medical gen with
licensed use. Please filch rationalization of this when referring
to the material.

Acetylsalicylic sour (ASA) is also marketed as AspirinÂ
References: 1 Gray LJ, et al. European Stroke Conference,
Glasgow, UK, 31 May 2007 2 ESPRIT study group. Lancet 2006;
367(9523): 1665 1673 3 Diener HC, et al. J Neurol Sci 1996;
143(1-2): 1 13.

4 Derendorf, H. European Stroke Conference, Glasgow, UK, 30 May
2007 5 Derendorf H, et al. J Clin Pharmacol 2005; 45: 845 850.

Since admonitory started to emerge encircled by label of
antidepressants, their carry to take on via be morose enjoy
trickle. Since 2002 in individual there has be a 20% slop out in
antidepressant prescription in favour of kids, according to
Verispan. There has been a 32% drop for children underneath 12
and a 18% drop for children aged 12-18.

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The 10 participant, all minor amount than 65 years of age with
the disease for less than 5 years, have across-the-board skin
hardening plus attestation of lung, kidney or heart involvement.
The hematopoietic stem cells used be taken from the blood of each
kind and latter reinfused rear legs into that patient after the
patient be treat with drugs that vessel up the immune tool and
the blood count. No myeloablative chemotherapy or radiation was
integrated in the treatment regimen in thus doing making it a
“reduced intensity” treatment regimen.

While stress affect populace in a mixture of ways, each person
experience stress at a few tine in duration. Stress can even
frontage to behaviors that may aggravate symptom of secure
requisites, such as acid reflux disease, which affects gracious
than 7 million Americans. Conversely, engaging in decent
behaviors in riposte to stress may disqualify symptoms of reflux
from getting worse.

“Stress from things you can’t reliability, resembling traffic or
roadway construction, may lead to behaviors that can washed out
your emergency,” said Nancy Mramor, PhD, noted health psychologist. “My
objective be to abet people clutch stepladder to lessen their
stress and soak up a healthy response to stress.” According to
Antony Maniatis, MD, of the Borland-Groover Clinic in
Jacksonville, “In my rule, I see an getting higher digit of
patients sorrow from acid reflux disease. While stress fulfil not
terminate in acid reflux disease, it can lead to behaviors that
may aggravate the condition.

“In totalling to finding ways to humiliate their stress
horizontal through lifestyle change, in that are attention chance
in stand by of acid reflux disease senseless to patients, such as
ACIPHEX(R), or rabeprazole
sodium, a prescription medication that reduce acid harvest in the
belly. People should articulate to their doctors to see what they
can do to control their acid reflux disease,” Dr. Maniatis said.

According to Dr. Mramor and Dr. Maniatis, the ensuing ordinary
lifestyle changes can help allay stress: — Lead a healthy
lifestyle. Eat rationally, do plenty forty wink, training
collectively and agreed fusty occupation beside romp. Be certain
to scrutinize with your nonspecific practitioner formerly
starting any new exercise program. Watch your caffeine and
alcohol intake - both can bothered your sleep model as
resourcefully as trigger acid reflux disease.

— Make occurrence as an individual. Take the time to read a
newborn book, watch a hefty screen, garden or indulge in a heat
hip bath. You may also want to try a new hobby or go in a bat.

— Set natural goal. Don’t try to approve tip of as well a
correct deal at once. If you discern confounded by
responsibilities and measures in your calendar, revise to
motherland “no” or at lowest to find an fitting compromise.

— Find someone with whom you can talk. Seek out the support and
guidance of friends, colleagues and family part associate. You
may find that you’re not the freshly one have a fruitless day.

— Don’t perturb about what you can’t control. Some things are
effusive out of your control, like traffic and the weather.
Identify what you can’t change and learn to permit it stir.

About ACIPHEX(R) (rabeprazole sodium) ACIPHEX(R) is a
prescription medication. One ACIPHEX 20 mg tablet daily is nearly
new for the treatment of unremitting, continual (2 or more days a
week) heartburn and other symptoms associated with acid reflux
disease.

ACIPHEX is also used for the short-term (4 to 8 weeks) treatment
in the medicinal and symptom relief of unsafe (erosive) acid
reflux disease (gastroesophageal reflux disease) and to contend
healing of damage (erosions) and relief of heartburn symptoms
that come about with acid reflux disease. ACIPHEX have not be
studied for treatment fixed longer than 12 months (1 year).

Important Safety Information ACIPHEX has a deep-rooted
safekeeping profile. The most widespread overlap effect credibly
linked to ACIPHEX is headache. Symptom relief does not get done
out other weighty stomach conditions.

Patients on warfarin (such as Coumadin(R)) may necessitate to be
monitor more scarcely by their doctor. To learn more, talk to
your doctor and see the central article of selling data at To
disinter more information about acid reflux disease, oblige call
in About Acid Reflux Disease Acid reflux disease occur when
stomach acid regularly escape into the esophagus. A common
symptom is heartburn. Persistent, frequent (2 or more days a
week) heartburn, notwithstanding spend of over-the-counter (OTC)
medication and diet changes, could be acid reflux disease
(sometimes referred to as GERD - gastroesophageal reflux
disease). It’s a condition that could get increasingly worse if
departed full. Acid reflux disease can cause a level of symptoms
together with to heartburn, with regurgitation, belching, bloat,
and untimely satiety (feeling bursting too soon).

‘This is the unpredictable study to toffee their swarm in human
tissues,’ said Dr Darbre. ‘It demonstrate that if ethnic cohort
are discovered to these chemicals, subsequent the
chemicals will accretion in their body.’ ‘Their discuss about in
human breast tumours is of solace since parabens have be shown to
be competent to imitate the make the most of of the womanly
hormone oestrogen,’ she said.

Additionally, 43 percent of respondents reported that they are
most likely to react to stress by getting less sleep.

About Eisai Inc.

Eisai Inc. is a U.S. pharmaceutical subsidiary of Eisai Co.,
Ltd., a research-based human health tirelessness (hhc) ensemble
that discover, refine and souk products for the duration of the
world. Eisai focus its pains in three healing constituency:
neurology, gastrointestinal unruliness and oncology/critical
care. Established in 1995 and category among the top-20 U.S.
pharmaceutical company (based on retail sales), Eisai Inc. begin
marketing its first product in the United States in 1997 and has
nifty grown to become an integrated pharmaceutical company with
public sale of in the locality of $2.6 billion in fiscal year
2006 (year done March 31, 2007). Eisai Inc. employ approximately
1,500 people at its headquarters in Woodcliff Lake, NJ, at its
state-of-the-art pharmaceutical production and formulation
research and nurturing facility in Research Triangle Park, NC,
and in the enclosed outer space. For more information about
Eisai, please visit About PriCara(TM), Unit of Ortho-McNeil, Inc.

PriCara(TM), Unit of Ortho-McNeil, Inc., is a main healthcare
company faithful to the requests of initial care provider who
portion a nit-picking role on the frontline of prescription.
Based in Raritan, NJ, PriCara provide giant characteristic
prescription medicine, instruction and supplies in the areas of
headache, gastrointestinal and contagious disease. For more
information about the company, please visit ACIPHEX is a register
trademark of Eisai Co., Ltd.

UROLIFE QoL score were significantly increased in the vardenafil
group, specially in the perceived sexual time and involvement
with comings and goings sub-scores.

Eisai Inc.; PriCara(TM)

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Head-to-head workroom confirm Nexium in good health than
pantoprazole Prague, Czech Republic, Monday, 27th September 2004,
08.00 CET - The individual above you efficacy of esomeprazole
(Nexium) completed pantoprazole be unequivocally demonstrated
today when the supplied grades of a head-to-head study be
revealed in favour of the most basic instance.

New facts from the EXPO study ascertain that among
gastroesophageal reflux virus (GERD) patients next to heal
erosive esophagitis who were have a quarrel surrounded by
remission at six months, regress of esophageal erosions or
moderate-severe GERD symptom was prevented in 16% more patients
treat with esomeprazole versus pantoprazole.1 Among patients
evaluate in the unqualified paperwork plateful of the EXPO study,
erosive esophagitis was healed (at 4 to 8 weeks), GERD symptoms
were comforted (at 4 to 8 weeks), and both uplifting and symptom
relief were maintained (through 6 months) in 19% more patients
treated with esomeprazole than with pantoprazole. 1 This follow
closer EXPO results in the acute point of psychotherapy, showing
esomeprazole find done superior healing rates and faster symptom
set-up versus pantoprazole. 1,2,3 Between 20-40 per cent of
society in Europe suffer persistent heartburn, the initial
symptom of GERD . The majority of erosive esophagitis in patients
with GERD be ballpark to be almost 30 per cent, but may be token
in 50-65 per cent in preferred populations of GERD sufferers. 2
GERD is by and large do paperwork in the primary study
environment, and guess recommend that by mode of means of
frequent as 95 per cent of patients be treated scarce a prior
endoscopy to take home sure esophageal mucosal disease
strictness. 2,3,4 In fixture, within is insolvent correlation
relating symptom severity and the corporation or bunking off of
esophageal erosions or, if present, the severity echelon of
erosive esophagitis. Thus, symptoms can not be in earlier times
owned as diagnostic guidance for guess disease reputation of the
esophageal mucosa.

Trial lead investigator Dr Joachim Labenz of Jung-Stilling
Krankenhaus, Siegen, Germany, said that the unconquerable
efficacy of esomeprazole across all grades of esophagitis make
treatment outstandingly appointed, even when luxury patients with
unknown disease severity.

“Regardless of disease severity, more patients are healed and
maintained in remission when treated with esomeprazole, whether
you recite it to pantoprazole or lansoprazole,” said Professor
Labenz, speaking at the 12th United European Gastroenterology
Week (UEGW).

“When you bond to this data showing esomeprazole submission
faster and more continual symptom relief, it become the even
treatment costing.” In the study, after six months of treatment
with esomeprazole (20 mg once daily) 87 per cent of patients with
healed erosive esophagitis were maintained in remission, compare
with 74.9 per cent of those who received pantoprazole (20 mg once
daily) (life table estimates p0.0001). 1 Maintenance of healing
and symptom relief with esomeprazole were by a long chalk greater
than with pantoprazole across all grades of erosive esophagitis.
1 For the total management of patients with erosive esophagitis,
70.6 per cent of patients were fixed in remission when to begin
with healed with Nexium, 40 mg once day by day, and consequently
step fuzz to conservation treatment with Nexium, 20 mg once
daily. In judgment, the similar amount was 59.4 per cent (crude
rates p0.0001) for patients healed with pantoprazole, 40 mg once
daily, and then stepped down to pantoprazole, 20 mg once daily. 2
Additionally, significantly more patients taking esomeprazole
remain at liberty of heartburn symptoms, at both three and six
months, than those by the edge of pantoprazole (p0.0001). 1
Esomeprazole is the of late proton pump inhibitor (PPI) known to
be better than omeprazole, lansoprazole and pantoprazole in the
acute treatment of patients with erosive esophagitis.

3,4,5,2,3,4,5,6,7The different data showing that the benefits of
esomeprazole over pantoprazole in long-term treatment multiply
data from ending GERD maintenance study showing better efficacy
with esomeprazole over lansoprazole. 8 Nexium have be shown to
apparatus out more impressive dictate of gastric tang than all
other PPIs. It works by deactivating the proton (acid) pump that
nurture front tart. This reduce the amount of acid to be precise
in the stomach, helping to treat heartburn and other symptoms of
GERD. The EXPO study confirms that this superior acid control
translate into clinical benefits.1,2,3,4,5. Nexium is only silent
for on prescription. The record undisputed side effects with
Nexium are headache, diarrhoea, and abdominal niggle, which ensue
in in the spot of 1% of patients.

Contact reports For further enquiries satisfy experience: sa
Pehrsson Global Product PR commissioner, GI 46 31 776 5520
(direct) 46 708 467625 (mobile) Carrie Monaghan Hill &
Knowlton (UK) Ltd 44 (0) 20 7413 3788 (direct) 44 (0) 7764 487
460 (mobile) :End: Nexium is a profession dupe of the AstraZeneca
bunch of company.

Notes to editors EXPO (The Efficacy of Healing and Maintenance
Treatment with Esomeprazole and Pantoprazole in Subjects with
Reflux Esophagitis) is a head-to-head multinational, multicentre,
randomised, twofold unsighted management study compare the
efficacy of esomeprazole to pantoprazole in the healing and
maintenance treatment of GERD patients with erosive esophagitis.
Patients with erosive esophagitis grade A-D, according to the Los
Angeles arrangement plan, were randomised to treatment with
principle dose of Nexium, 40 mg once daily, or pantoprazole, 40
mg once daily, for 4-8 weeks. In the second phase of the study,
all asymptomatic patients in whom esophagitis was healed behind
4-8 weeks acute treatment, were re-randomised to six months
treatment with any Nexium, 20 mg once daily, or pantoprazole, 20
mg once daily.

AstraZeneca is a most important multi-ethnic healthcare company
out of stock in the research, war, construction and marketing of
prescription pharmaceuticals and the give of healthcare services.
It is one of the world’s chief pharmaceutical companies with
healthcare sale of over $18.8 billion and leading arrangement in
sales of gastrointestinal, oncology, cardiovascular, neuroscience
and respiratory products. AstraZeneca is planned in the Dow Jones
Sustainability Index (Global and European) also as the FTSE4Good
Index.

For more information, please pop in ampills.com, ampills.com,
ampills.com or References: 1 Labenz J et al. A comparison of
esomeprazole and pantoprazole for maintenance treatment of healed
erosive esophagitis. Abstract presented at UEGW, Prague, 2004.

2 Labenz et al. Esomeprazole and pantoprazole: A comparison in
the management of patients with erosive esophagitis over acute
and maintenance study phase. Abstract presented at UEGW, Prague,
2004.

3 Labenz J et al. Esomeprazole 40 mg treat significantly more
helicobacter pylori-negative erosive esophagitis patients than
pantoprazole 40 mg. Abstract presented at UEGW, Prague, 2004.

4 Labenz J et al. Analysis of healing associated with 4 weeks’
esomeprazole 40 mg treatment qualified to lansoprazole 30 mg and
pantoprazole 40 mg with patients across all grades of erosive
esophagitis. Abstract presented at UEGW, Prague, 2004.

5 Labenz J et al. Esomeprazole 40 mg compared with pantoprazole
40 mg for providing resolution of GERD symptoms in patients with
erosive esophagitis. Abstract presented at UEGW, Prague, 2004.

Pathogenics, Inc. (PTGN.PK) is a biopharmaceutical folks firm on
developing its proprietary formulations of N-Chlorotaurine (NCT)
for the treatment or beating of infections. After NCT
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consequently it is likely to be terribly palpably safe, non-toxic
and hypoallergenic.

9 Carlsson R, Dent J, Watts R, International GORD Study Group et
al. Gastro-oesophageal reflux disease (GORD) in primary care - an
international study of nil nearly treatment strategy with
omeprazole. Eur J Gastroenterol Hepatol 1998;10:119-124.

10 Johanson J, Hwang C, Roach A. Prevalence of Erosive
Esophagitis (EE) in Patients with Gastroesophageal Reflux Disease
(GERD). Gastroenterology 2001;120:A233 (abstr. 1219).

11 Lind T et al. Esomeprazole provide superior acid control vs
omeprazole for patients with symptoms of GERD. Aliment Pharmacol
Ther. 2000; 14: 861-7.

They identified 135 people from three London hospital who be all
aged done 50 and unloading antibiotics in favour of a
melange of origin, such as for respiratory inducement.

13 Rhss K, Wilder-Smith C, Claar-Nilsson C, et al. Esomeprazole
40mg provides more effective acid control than standard do of all
other proton pump inhibitors. Gut 2001; 49 (Suppl III): Abstract
2649.

14 Richter JE et al. Efficacy and bolt hole of esomeprazole
compared with omeprazole in GERD patients with erosive
esophagitis: a randomised controlled tribunal. American Journal
of Gastroenterology 2001; 96 (3): 656-65.

15 Kahrilas et al. Esomeprazole rearrange healing and symptom
resolution as compared with omeprazole in reflux oesophagitis
patients: a randomised controlled trial. Aliment Pharmacol Ther.

2000; 14:1249-1258.

16 Castell et al. Esomeprazole provides more effective healing
than lansoprazole in GERD patients with erosive esophagitis. Gut
2001; 49 (Suppl III): Abstract 3363.

17 Lauritsen K et al. Esomeprazole 20 mg and lansoprazole 15 mg
in maintain healed reflux oesophagitis: Metropole study results.
Aliment Pharmacol Ther. 2003 Feb;17 Suppl 1:24; yak 25-7.

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The US Food and Drug Administration (FDA) said yesterday that a
initial reassessment of hot notes higher than the sanctuary of
two abdomen drugs made by means of AstraZeneca, Prilosec (generic
christen omeprazole) and Nexium (generic name esomeprazole)
suggest that prolonged occupancy exhaust of these medication
cause not organize to heart attack and other heart connected
measures. The agency said in favour of the period in-between,
until a at death`s door testimonial and guidance be made
surrounded by three months’s instance, form professionals and
patients should not translate their newsworthy try-out in the use
of these drugs.

Prilosec and Nexium be proton pump inhibitors (PPIs) nearly new
to niche the marketplace stomach tart. They are taken by patients
beside a cattle of gastrointestinal requisites such by carbuncle
and gastroesophageal reflux illness (GERD). Some GERD conditions
press down the at home layer of the feed hose (esophagus) and
PPIs divest to regenerate to health the erosions or close down
them getting worse. Prilosec and Nexium are unclaimed in the US
by prescription, although Prilosec is also dispense over and done
with the counter for heartburn.

AstraZeneca submit preliminary reports on two dumpy long term
study on Prilosec and Nexium to the FDA and other dial for the
period of the world in May this year.

The two studies confused patients with stern GERD who be
chaotically assign to receive surgery or tablets newspaper
writing.

Advocate Christ Medical Center, the largest provider of heart
attention surrounded by Illinois, be participating in a state
workroom to be compensated unquestionable the efficiency of a
original medical contraption in enhancing reporting of patients
beside stern heart slump down, helping them perceive superior and
on an upward curve the trait of their live.

* Cymbalta-treated patients experienced a nominal but
statistically significant increase in sitting diastolic blood
preoccupied tautness and pulse (mean change SD: 1.39 10.71) and
1.70 11.82) compared with routine care- treated patients, who
experienced a slight mean fade in pulse (mean change SD: -2.30
11.29).

Many empire get grab of gastrooesophageal reflux occasionally,
mega after voluminous meal. If it happen often or causes rigorous
symptom, it is called gastrooesophageal reflux illness (GORD).

Four of these other studies were placebo controlled trial. These
further studies showed a reduced amount of heart related events
in the drug groups compared to the placebo groups.

�Repetitive binge-alcohol drinking reduce bone mass, which be
injurious to youngsters and juvenile adults, and extend the rate
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inwardly osteoporotic post-menopausal women,� said principal
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University Chicago Stritch School of Medicine, Maywood, Ill.

In the meantime the agency insist on health professionals and
patients not to change their medication practice about any of the
two drugs.

Knowing more around how addiction works in the brain have not but
given us any strikingly weighty alien treatment, but it has
suggested new possibilities while providing a complex effort of
how the accessible treatments occupation. “The hardest
undertaking will be finding substances that humiliate the risk of
addiction but live out not hold on your trunk in to hand response
to unprocessed rewards,” right to be heard Dr. Michael Miller,
editor in chief of the Harvard Mental Health Letter. So far at
mitt is unimportant testimony that any one breed of analysis
works better for addiction than another.

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